Engineering & Systems Architecture

Decoupled Diagnostic Topology

BiQadx instrument architecture is fundamentally modular. By decoupling pre-analytical sample preparation (specimen intake, sonication-induced cell lysis, acoustofluidic separation) from analytical observation (time-resolved fluorescence, potentiometry, turbidimetry), we eliminate single points of failure inherent in monolithic "black box" analyzer designs.

The "Architecture First" Principle

Traditional analyzers utilize centralized pneumatic gating, shared fluidic routing, and sequential optical interrogation. If a single stepper motor or solenoid valve fails, the entire diagnostic sequence aborts. BiQadx abandons this paradigm in favor of distributed, asynchronous, hardware-accelerated processing nodes.

For example, our HELIX ONE intake architecture physically isolates raw biological handling from the downstream observation matrix. It achieves high-purity fraction extraction via localized 2 MHz ultrasonic standing waves, generating controlled radiation pressure that stratifies leukocytes from erythrocytes (label-free and lysis-free) in under 90 seconds. The resulting plasma fraction is then dispensed to independent optical/electrochemical testing stages (like Dr. POCT) via valveless, centrifugal Coriolis force microfluidics.

2 MHz Standing Acoustic Wave Line Vector

Assay Integration & Clinical Deployment

Current R&D and deployment matrices mapping BiQadx hardware architectures to specific diagnostic biomarker panels.

01
R&D — TRL 3

Sepsis (DTC Panel)

34-pathogen identification. Culture-independent isolation from whole blood. Real-time quantification of Procalcitonin (PCT), CRP, and IL-6 via turbidimetric assay. Target TAT < 90 min.

Domain Architecture →
02
Prototype — TRL 4

AST (Microbial Mapping)

Optical density tracking across 96-well micro-carriers. Tracks individual bacterial replication rates under antibiotic stress.

Domain Architecture →
03
R&D — TRL 3

Respiratory Syndromic

Multiplex electrochemical SPCE panel: Influenza A/B, RSV, SARS-CoV-2. Simultaneous 4-plex binding detection via lateral flow on the ViroSnap framework.

Domain Architecture →
04
Pilot — TRL 5

Critical Care (Blood Gas)

Amperometric & Potentiometric ISE array. Measures pO2, pCO2, pH, Na+, K+, Ca++, Cl-, Glucose, Lactate.

Domain Architecture →
05
Prototype — TRL 4

Cardiac Triage

Time-resolved fluorescence immunoassay for High-Sensitivity Troponin I (hs-TnI) and NT-proBNP. Utilizes COP substrates.

Domain Architecture →
06
Concept — TRL 2

Metabolic Function

Multi-analyte lipid and organ-function panel leveraging lyophilized bead chemistry within centrifugal disc chambers.

Domain Architecture →
07
Concept — TRL 1–2

Oncology Marker Triage

Multi-channel fluorescence decay curve analysis using quantized transformer models to classify complex early-stage oncological protein markers.

Domain Architecture →
08
Concept — TRL 1–2

Veterinary (Vector-Borne)

Decentralized 4-plex POCT panel targeting Ehrlichia, Lyme, Anaplasma, and Heartworm via whole-blood acoustic separation.

Domain Architecture →

Innovation Studio Themes

Hardware + AI Co-Design

Silicon architecture and inference logic are built concurrently, ensuring the analyzer's optical and sensor layers are natively aware of the AI model's computational needs.

Closed-Loop Workflow

Intelligent routing algorithms manage physical cartridge transit and fluidic sequencing without user intervention, from raw specimen to final result.

Zero-Trust LIMS Node

HL7/FHIR R4 structured output with edge-first computing. No cloud dependency. Patient data never leaves the clinical site.